An Investigator Has Conducted a Study Where She Is Interested

Essay

An investigator has conducted a study where she is interested in how the amount of cadmium found in well water affects the glomerular filtration rate (GFR). The GFR can be used to assess kidney function in individuals. The investigator has collected information on potential confounders but is really interested in the relationship between cadmium levels and GFR. Describe in detail the differences in sequential sums of squares and adjusted sums or squares in the context of this problem. How might these sums of squares help the investigator to understand the contribution of cadmium levels and of confounders?