In Addition to an Increase in Sensitivity to Glutamate, the Binding

Multiple Choice

In addition to an increase in sensitivity to glutamate, the binding of large amounts of glutamate to its receptors on the postsynaptic membrane also

A) can overwhelm the synapse.
B) stimulates presynaptic autoreceptors and enhances its release.
C) affects other synapses that are close to the first.
D) directly causes more NMDA channels to open.
E) stimulates the release of a paracrine messenger that further increases glutamate release.