Which Statement Best Describes Why Estrogen May Contribute to Osteoporosis

Multiple Choice

Which statement best describes why estrogen may contribute to osteoporosis?

A) A decrease in estrogen stimulates the production of interleukin -6 that then stimulates osteoclast activity.
B) A decrease in estrogen causes a corresponding decrease in interleukin -6 that then lowers calcium levels.
C) A decrease in estrogen stimulates an increase in osteoblast activity due to the activation of 1,25 -(OH₂) D_3.
D) A decrease in estrogen stimulates calcitonin secretion from the pituitary gland.
E) Estrogen is a steroid hormone that interferes with calcium resorption.