A Clinical Lab Scientist Was Performing a Cytogenetic Analysis, and 10

Multiple Choice

A clinical lab scientist was performing a cytogenetic analysis, and 10 of the chromosome spreads she analyzed had 46 normal chromosomes. In the 11th spread, she noticed 47 chromosomes. What is the first thing she should do?

A) Repeat the slide preparation to exclude errors that would cause chromosome artifacts.
B) Repeat the slide preparation with a different stain.
C) Examine more chromosomes spreads using to FISH try to confirm the presence of a genetic mosaic.
D) Report a normal karyotype of 46 chromosomes.