A Researcher Finds a Mutant Mouse with a Phenotype That

Multiple Choice

A researcher finds a mutant mouse with a phenotype that may have applications to human disease. What would be the most efficient means of identifying the mutated gene?

A) Use a microarray to identify transcribed genes.
B) Sequence the entire genome of the mutant.
C) Use DNA fingerprinting to identify an altered DNA fragment, sequence it and search a gene library.
D) Search a mouse gene library.
E) Use DNA fingerprinting to identify a DNA fragment of altered size.