The Development of a Cancerous Cell Is Said to Require

Multiple Choice

The development of a cancerous cell is said to require ʺmultiple hits.ʺ This means

A) multiple cell cycle regulators are inactivated at once.
B) multiple oncogenic viruses infect the cell at the same time.
C) a series of separate events over time lead to the loss of cell cycle regulation.
D) the cell must be infected with several different types of viruses to be transformed.
E) several protoncogenes are activated at the same time.