A Phenotypically Normal Prospective Couple Seeks Genetic Counseling Because the Man

Multiple Choice

A phenotypically normal prospective couple seeks genetic counseling because the man knows that he has a translocation of a portion of his chromosome 4, which has been exchanged with a portion of his chromosome 12. Although his translocation is balanced, he and his wife want to know the probability that his sperm will be abnormal. What is your prognosis regarding his sperm?

A) One-quarter will carry the two normal chromosomes, 4 and 12, one-quarter will have only the two translocation chromosomes and no normal chromosomes 4 and 12, and half will have one normal and one translocated chromosome.
B) All will carry the same translocation as the father.
C) None will carry the translocation.
D) Half will be normal, and the rest will have the father's translocation.