Rank the Following One-Base Point Mutations with Respect to Their

Multiple Choice

Rank the following one-base point mutations with respect to their likelihood of affecting the structure of the corresponding polypeptide (from most likely to least likely) .
1) insertion mutation deep within an intron
2) substitution mutation at the third position of a codon in an exon
3) substitution mutation at the second position of a codon in an exon
4) deletion mutation within the first exon of the gene

A) 1, 2, 3, 4
B) 4, 3, 2, 1
C) 2, 1, 4, 3
D) 3, 1, 4, 2