Which of the Following Is Not a Way Changes Affecting

Multiple Choice

Which of the following is not a way changes affecting evolution occur in the regulatory gene network for heart development that is conserved from Drosophila to mammals?

A) substitution of transcription factor families in the network
B) mutations in the cis-element that change its binding affinity
C) mutation in cis-elements that allow it to bind to different transcription factors
D) repositioning of cis-elements
E) insertion or deletion of cis-elements