During Fatty Acid Oxidation, a Fatty Acid Must React with Coenzyme

Multiple Choice

During fatty acid oxidation, a fatty acid must react with coenzyme A to become a fatty acyl-CoA, as shown below. In the body, the reaction above is coupled to the hydrolysis of two phosphate groups from ATP as shown below: Which of the following equations is the correct calculation of the overall free energy of the coupled reaction?

A) ΔG_overall = 7.0 kcal/mol + 15.7 kcal/mol
B) ΔG_overall = 7.0 kcal/mol  15.7 kcal/mol
C) ΔG_overall = 15.7 kcal/mol + 7.0 kcal/mol
D) ΔG_overall = 7 kcal/mol  15.7 kcal/mol
E) ΔG_overall = 7 kcal/mol  15.7 kcal/mol