Which Statement Best Describes How an Enzyme Lowers the Activation

Multiple Choice

Which statement best describes how an enzyme lowers the activation energy of a reaction?

A) The enzyme covalently binds to the substrate, lowering its energy.
B) The enzyme chemically reacts with the substrate to make it more reactive.
C) The enzyme increases the temperature of the substrate, making it more reactive.
D) The substrate is held in the correct orientation for reaction to occur.
E) All of the above