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Phenylephrine (PE; See the Structure Below) Is a Nasal Decongestant

Question 26

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Phenylephrine (PE; see the structure below) is a nasal decongestant and is the active ingredient in Sudafed, which contains phenylephrine hydrochloride (PEHCl) .This conjugate acid of phenylephrine (PEH+) has a pKa= 5.5.At a physiological pH of 7.4, what is the ratio of concentrations, [PE]/[PEH+]? Phenylephrine (PE; see the structure below)  is a nasal decongestant and is the active ingredient in Sudafed, which contains phenylephrine hydrochloride (PEHCl) .This conjugate acid of phenylephrine (PEH<sup>+</sup>)  has a pK<sub>a</sub>= 5.5.At a physiological pH of 7.4, what is the ratio of concentrations, [PE]/[PEH<sup>+</sup>]?   A) 6.7 B) 0.01 C) 0.14 D) 79 E) 21


A) 6.7
B) 0.01
C) 0.14
D) 79
E) 21

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