At What Point in the Drug Approval Process Was It

Multiple Choice

At what point in the drug approval process was it discovered that the pain medication Vioxx® increased the risk of cardiac events?

A) During preclinical animal studies.
B) During Phase I studies in healthy volunteers.
C) During Phase III studies with a large number of individuals with the symptom of interest pain) .
D) During the post-marketing period when the manufacturer was attempting to show the superiority of the drug over its competitors.