In Leber's Disease (LHON), Degeneration of the Optic Nerve Results

Multiple Choice

In Leber's disease (LHON) , degeneration of the optic nerve results in blindness due to a defect in NA dehydrogenase affecting electron transport. If this is due to a mutation in a mitochondrial gene, whi combination of the following effects would you expect to see when doing a pedigree analysis of a fa with LHON? i. variable expressivity
ii. incomplete penetrance
iii. progressive blindness over time
iv. maternal inheritance
v. diminished muscle mass

A) ii and iii only
B) i, ii, iii, and iv only
C) iii and iv only
D) i, ii, iii, and v only
E) i and ii only