The Reverse Reaction of Nucleic Acid Synthesis Almost Never Happens

Multiple Choice

The reverse reaction of nucleic acid synthesis almost never happens. What prevents it?

A) The enzyme does not work in reverse.
B) Polynucleotides are too stable to depolymerize.
C) H bonds holding the strands together are too strong.
D) Nucleic acid synthesis is coupled to the highly exergonic pyrophosphate hydrolysis.
E) There is a large uptake of free energy.