Which of the Following Can Lead to an Increase or Decrease

Multiple Choice

Which of the following can lead to an increase or decrease in the number of chromosomes over time and can thus provide a clear visual footprint of the evolutionary process? (Select all correct choices)

A) a simple loss of chromosomes during a mitotic event
B) complete fragmentation of a chromosome
C) the splitting of a chromosome
D) the fusion of two chromosomes into one chromosome