How Do Integral Membrane Proteins Enter the Lipid Bilayer

Multiple Choice

How do integral membrane proteins enter the lipid bilayer?

A) They insert into the membrane from the RER lumen after their synthesis is complete.
B) The aqueous translocon channel has a gate that continuously opens and closes, giving each nascent polypeptide segment a chance to partition itself into the lipid bilayer's hydrophobic core.
C) They insert into the membrane from the cytosol after their synthesis is complete.
D) The membrane is disrupted and proteins are incorporated during reassembly.