What Is the Basis for the Difference in How the Leading

Multiple Choice

What is the basis for the difference in how the leading and lagging strands of DNA molecules are synthesized?

A) The origins of replication occur only at the 5' end.
B) Helicases and single-strand binding proteins work at the 5' end.
C) DNA polymerase can join new nucleotides only to the 3' end of a growing strand.
D) DNA ligase works only in the 3' → 5' direction.
E) Polymerase can work on only one strand at a time.