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One Hereditary Disease in Humans, Called Xeroderma Pigmentosum (XP), Makes

Question 43

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One hereditary disease in humans, called xeroderma pigmentosum (XP) , makes homozygous individuals exceptionally susceptible to UV-induced mutation damage in the cells of exposed tissue, especially skin. Without extraordinary avoidance of sunlight exposure, patients soon succumb to numerous skin cancers.
-Given the damage caused by UV, the kind of gene affected in those with XP is one whose product is involved with


A) mending of double-strand breaks in the DNA backbone.
B) breakage of cross-strand covalent bonds.
C) the ability to excise single-strand damage and replace it.
D) the removal of double-strand damaged areas.
E) causing affected skin cells to undergo apoptosis.

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