Essay
Cyclooxygenase 2 is expressed primarily as part of the inflammatory response, whereas cyclooxygenase 1 is expressed more generally. Celecoxib (Celebrex) was designed to target COX2 and is used to reduce inflammation due to arthritis. What structural feature of Celecoxib (Celebrex) makes this drug more selective for COX2 instead of COX1?
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X-ray crystallography of COX2 revealed a...View Answer
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