How Can the Leading and Lagging Strands Be Synthesized in a Coordinated

Multiple Choice

How can the leading and lagging strands be synthesized in a coordinated fashion?

A) Specific enzymes control the size of the DNA opening.
B) Lagging-strand binding proteins inhibit leading-strand replication if the strands become disproportionate in size.
C) DNA polymerase III is a dimeric holoenzyme, and the looped lagging strand allows the enzyme to proceed in the same direction with each strand.
D) Leading and lagging strand syntheses are catalyzed by two distinct and noninteracting replisomes, but the rate is controlled by helicase.
E) None of the answers is correct.