Which Enzyme(s), in Nucleotide Biosynthesis Pathways, Use(s) a Substrate Channeling

Multiple Choice

Which enzyme(s) , in nucleotide biosynthesis pathways, use(s) a substrate channeling mechanism?

A) carbamoyl phosphate synthetase
B) nucleoside monophosphate kinase
C) glutamine phosphoribosyl amidotransferase
D) aspartate transcarbamoylase
E) carbamoyl phosphate synthetase and glutamine phosphoribosyl amidotransferase