Binding of a Water Molecule to the Zinc Ion Induces

Multiple Choice

Binding of a water molecule to the zinc ion induces

A) a hydronium ion to form.
B) a large conformation change in the binding site.
C) ionization of a His residue, which functions as a strong nucleophile.
D) a lowered pK_a for water, which leads to formation of a zinc bound hydroxide ion.
E) an altered K_M value.