What Is the Best Method to Prevent Warfarin-Induced Skin Necrosis

Multiple Choice

What is the best method to prevent warfarin-induced skin necrosis during treatment for thrombosis?

A) Use higher dose of warfarin early in treatment.
B) Give the patient injections of protein C.
C) Stop warfarin at the first sign of necrosis.
D) Use heparin for first 5 days in conjunction with warfarin.