Suppose That You Are a Genetic Counsellor, and a Couple

Multiple Choice

Suppose that you are a genetic counsellor, and a couple comes to you with concerns that if they have a child together, it could have hemophilia. Suppose also that neither one of them has hemophilia, but the woman's biological father did have an X-linked recessive form of hemophilia. Which of the following is the best advice you could give them?

A) Each of their male offspring will have hemophilia, and each of their female offspring will have a 50% chance of having hemophilia.
B) None of their offspring should have hemophilia, but each of their female offspring will be carriers for hemophilia.
C) Each child that they produce will have a 50% chance of having hemophilia.
D) Each of their male offspring will have a 50% chance of having hemophilia, and while their female offspring should not have hemophilia, they will each have a 50% chance of being carriers.