Which Description Is Consistent with Chronic Myelogenous Leukemia (CML)

Multiple Choice

Which description is consistent with chronic myelogenous leukemia (CML) ?

A) Defects exist in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the gene encoding a cell-cycle regulatory protein.
B) Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes, and erythrocytes.
C) B cells fail to mature into plasma cells that synthesize immunoglobulins.
D) The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein identified as BCR-ABL1.