In Osteoarthritis,what Is the Effect of the Disruption of the Pumping

Multiple Choice

In osteoarthritis,what is the effect of the disruption of the pumping action of proteoglycans?

A) Pump malfunction stimulates the induction of nitric oxide synthase and nitric oxide, which degrades the cartilage.
B) Cartilage is damaged by proteolytic enzymes because they cannot be pumped out of the joint.
C) Cartilage becomes dry, brittle, and wears away because fluid cannot be pumped into the cartilage.
D) Cartilage takes in too much fluid and is unable to withstand the stresses of weight bearing.