A Loss of Function of Apaf1, the Human Homologue of Ced-4

Multiple Choice

A loss of function of Apaf1, the human homologue of ced-4 in nematodes, is most likely to result in which of the following?

A) activation of a developmental pathway found in the nematode but not in humans
B) a form of cancer in which normal apoptosis fails
C) excess activation of the human analog of the ced-3 protease
D) extensive tissue damage due to excess apoptosis