When Attempting to Introduce a Particular Fragment of DNA into the Genome

Multiple Choice

When attempting to introduce a particular fragment of DNA into the genome of an animal cell which of the following methods would be most successful?

A) CRISPR/Cas9 recombination
B) in vitro hybridization of the DNA with the cell's genome
C) infecting the mouse cell with a Ti plasmid
D) RNA-seq followed by genetic profiling