Which of the Following Mutations Would Be Most Likely to Have

Multiple Choice

Which of the following mutations would be most likely to have a harmful effect on an organism?

A) a deletion of three nucleotides near the middle of a gene
B) a single nucleotide deletion in the middle of an intron
C) a single nucleotide deletion near the end of the coding sequence
D) a single nucleotide insertion downstream of, and close to, the start of the coding sequence