Which of the Following Would Cause the Greatest Degree of Hypokalemia

Multiple Choice

Which of the following would cause the greatest degree of hypokalemia?

A) Long-term treatment with a diuretic such as spironolactone that inhibits the action of aldosterone
B) Long-term treatment with a diuretic such as amiloride that inhibits sodium reabsorption in the late collecting ducts
C) Long-term treatment with a diuretic such as furosemide that inhibits loop of Henle Na⁺-2Cl^- K⁺ co-transport
D) An increase in sodium intake from 150 to 300 mmol/day
E) A reduction in potassium intake from 160 to 80 mmol/day in a person with normal kidneys and normal aldosterone system