The Abnormal Cleavage of Mannose Residues During the Posttranslational Processing

Multiple Choice

The abnormal cleavage of mannose residues during the posttranslational processing of glycoproteins has been shown to result in the development of a lupus-like autoimmune disease in mice. The abnormal cleavage is due to a mutation of the enzyme -mannosidase II. Based on your understanding of the processing of membrane proteins, you would predict this enzyme to be localized to which of the following?

A) Nucleus
B) Cytosol
C) Golgi apparatus
D) Lysosomes
E) Peroxisomes