The Enzyme Phosphoglucose Isomerase Converts Glucose 6-Phosphate to Its Isomer

Multiple Choice

The enzyme phosphoglucose isomerase converts glucose 6-phosphate to its isomer fructose 6-phosphate in the second step of glycolysis. The equilibrium constant for the reaction is 0.36. Evaluating the ΔG° of the reaction (ΔG° = -5.9 × log Kₑq) , decide which of the following conclusions is true.

A) The ΔG° is negative, therefore the reaction proceeds in the forward direction.
B) The ΔG° is negative, but whether or not the reaction proceeds would depend on ΔG, not ΔG°.
C) The ΔG° is positive, but in a cell that is active in glycolysis, the reaction can still proceed in the forward direction.
D) The ΔG° is positive, therefore the reaction proceeds in the reverse direction.