The Human Estrogen Receptor Is a Symmetrical Dimeric Nuclear Protein

Multiple Choice

The human estrogen receptor is a symmetrical dimeric nuclear protein that can regulate gene expression by binding to a DNA sequence called an estrogen response element (ERE) near the promoter of its target genes. Each subunit of the receptor binds to about six base pairs of DNA. Which of the following sequences is a likely candidate for the ERE? The sequences are written in the 5′-to-3′ direction. The letter N represents any of the four DNA bases.

A) AGGTCANNNTGACCT
B) AGGTCANNNAGGTCA
C) AGGTCANNNACTGGA
D) AGGTCANNNATATAT
E) AGGCCTNNNTCATGA