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The Microtubule-Binding Protein Patronin Binds to the Minus Ends of Microtubules

Question 3

Multiple Choice

The microtubule-binding protein Patronin binds to the minus ends of microtubules at the spindle pole and protects them from the effect of catastrophe factors. If Patronin activity is inhibited by injecting an anti-Patronin antibody into Drosophila melanogaster embryos prior to cellularization, anaphase B is suppressed and the spindles are significantly shorter. Which of the forces (1 or 2) in the following schematic diagram do you think is mostly responsible for anaphase B in this organism at this stage? Does the effect of Patronin inhibition resemble that of kinesin-5 inhibition (I) or overactivation (O) ? The microtubule-binding protein Patronin binds to the minus ends of microtubules at the spindle pole and protects them from the effect of catastrophe factors. If Patronin activity is inhibited by injecting an anti-Patronin antibody into Drosophila melanogaster embryos prior to cellularization, anaphase B is suppressed and the spindles are significantly shorter. Which of the forces (1 or 2) in the following schematic diagram do you think is mostly responsible for anaphase B in this organism at this stage? Does the effect of Patronin inhibition resemble that of kinesin-5 inhibition (I) or overactivation (O) ? A) 1; I B) 1; O C) 2; I D) 2; O


A) 1; I
B) 1; O
C) 2; I
D) 2; O

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