Three Fundamental Controls Seem to Have Been Subverted in Essentially

Short Answer

Three fundamental controls seem to have been subverted in essentially every type of cancer. Choose these three among the following regulatory axes. Your answer would be a three-letter string composed of letters A to F only, in alphabetical order, e.g. BDF.
(A) Wnt pathway
(B) Rb pathway
(C) RTK/Ras/PI3K pathway
(D) p53 pathway
(E) Hippo pathway
(F) GPCR/PKA pathway