Using Cre Recombination, the Gene Encoding Stem Cell Factor (SCF)

Multiple Choice

Using Cre recombination, the gene encoding stem cell factor (SCF) can be deleted in specific cell types in adult mice. Deletion of this gene in which of the following cells would you expect to lead to the most significant depletion of hematopoietic stem cells in the bone marrow?

A) Osteoblasts
B) Osteoclasts
C) Stromal cells
D) Hematopoietic stem cells
E) Common myeloid precursor cells