If Mice Are Injected with Antibodies Against Selectin Homing Receptors

Multiple Choice

If mice are injected with antibodies against selectin homing receptors or against the integrin ligand I-CAM1 (which is expressed on the surface of endothelial cells) , they show immune defects, such as higher susceptibility to bacterial infections. Which of the following properties of lymphocytes at endothelial cells would you expect to observe after injection with both antibodies?

A) Normal lymphocyte rolling and normal lymphocyte adhesion
B) Impaired lymphocyte rolling but normal lymphocyte adhesion
C) Normal lymphocyte rolling but impaired lymphocyte adhesion
D) Impaired lymphocyte rolling and impaired lymphocyte adhesion