Which of These Determines the Tertiary Structure of a Protein

Multiple Choice

Which of these determines the tertiary structure of a protein?

A) Sequence of amino acids
B) Ratio of the number of acidic amino acids to the number of basic amino acids
C) Number of alpha helices and pleated sheets along the axis of the protein
D) Number of carbon bonds in the chain of amino acids
E) Interactions between amino acids separated by significant distances on the protein chain