Which Observation Would Provide the Most Definitive Diagnosis of Syphilis

Multiple Choice

Which observation would provide the most definitive diagnosis of syphilis?

A) Observation of chancres
B) A fever and a rash on hands and feet
C) Observation of discharge from the penis or vagina
D) Detection of antibodies to Treponema pallidum in the blood
E) Knowledge that the person in question had sex with an infected partner