What Is the A/D Ratio

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The Answer is It is a ratio of adult to development toxicity. The assumption of this ratio which is not consistent across species is that maternal toxicity for viviparous (live birth) animals is responsible for most developmental abnormalities. This is clearly not the case for chemicals such as thalidomide which specifically binds to the cereblon protein preventing limb outgrowth and fibroblast growth factor Tgf8 expression without maternal toxicity.

What Is the A/D Ratio

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What Is the A/D Ratio

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