Linus Pauling Was Interested in Studying Sickle Cell Disease at the Molecular

Multiple Choice

Linus Pauling was interested in studying sickle cell disease at the molecular level. In examining the hemoglobin proteins associated with healthy people and those with sickle cell disease (HbA and HbS) , he discovered that:

A) The proteins were chemically identical, but HbS forms long filaments under low oxygen conditions, which deform red blood cells.
B) The proteins were chemically different, and HbS forms long filaments under low oxygen conditions, which deform the red blood cells.
C) The proteins were chemically inert except under conditions of low oxygen.
D) It was not possible to distinguish the disease related protein at the molecular level.
E) Both proteins formed long filaments under low oxygen conditions, but only HbS resulted in deformed red blood cells.