Using the table of classification of recommendations, indicate how the following evidence should be graded: Well-conducted, randomized controlled trials and over a decade of use in clinical practice indicate that a large proportion of breast cancer can be cured among women with early breast cancer if the treatment is used on women with early breast cancer.

\text { Classification of Recommendations }

\begin{array}{|l|l|l|l|l|}\hline \begin{array}{l}\text { Quality of the } \\\text { Evidence }\end{array} & \begin{array}{l}\text { Net Benefit } \\\text { Substantial }\end{array} & \begin{array}{l}\text { Net Benefit } \\\text { Moderate }\end{array} & \begin{array}{l}\text { Net Benefit } \\\text { Small }\end{array} & \begin{array}{l}\text { Net Benefit } \\\text { Zero/negative }\end{array} \\\hline \text { Good } & \text { A } & \text { B } & \text { C } & \text { D } \\\hline \text { Fair } & \text { B } & \text { B } & \text { C } & \text { D } \\\hline \text { Poor } & \text { I } & \text { I } & \text { I } & \text { I }\\\hline\end{array}

\text { Adapted from United States Preventive Services Task Force. }

A) Grade A
B) Grade B
C) Grade C
D) Grade D
E) Grade I

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