One of the Earliest and Most Profound Changes Found in Patients

Multiple Choice

One of the earliest and most profound changes found in patients with Alzheimer's disease is

A) death of substantia nigra dopaminergic neurons.
B) death of striatal GABAergic neurons.
C) death of raphe serotonergic neurons.
D) loss of the subthalamic neurons.
E) degeneration of the basal forebrain cholinergic neurons.