Ionotropic Nicotinic Acetylcholine Receptors Are Known to Excite Cells Based

Multiple Choice

Ionotropic nicotinic acetylcholine receptors are known to excite cells based on the flux of sodium ions into the cell cytoplasm when these channels are activated near resting membrane potential. However, how can the calcium flux through these receptors lead to an inhibitory influence?

A) Calcium flux through nicotinic receptors can act back on the nicotinic receptor to inhibit it.
B) Calcium flux through nicotinic receptors directly depolarizes the cell.
C) Calcium flux through nicotinic receptors directly hyperpolarizes the cell.
D) Calcium flux through nicotinic receptors can activate a calcium-activated potassium channel whose potassium flux hyperpolarizes the cell.
E) Calcium flux through nicotinic receptors can activate a calcium-activated potassium channel whose potassium flux depolarizes the cell.