Multiple Choice
How do developmental changes in chloride transporter expression affect GABAergic transmission?
A) The developmental switch from NKCC1 to KCC2 allows GABA to become depolarizing.
B) Changes in chloride transporter expression do not alter GABAergic transmission.
C) In the immature brain, GABA transporters can transport both glutamate and GABA. The delayed expression of KCC2 promotes the substrate specificity of GABA transporters.
D) Developmental changes in chloride transporters allow GABAergic transmission to have faster kinetics.
E) The delayed expression of KCC2 allows GABA to evoke membrane hyperpolarization in the mature, not the immature brain.
Correct Answer:
Verified
Correct Answer:
Verified
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