In the Rotational Model of Sodium Channel Activation, What Happens

Multiple Choice

In the rotational model of sodium channel activation, what happens when the membrane is depolarized?

A) An activation "gate" on the N-terminus of the protein swings open, allowing ions to move.
B) A short loop between domains III and IV swings open to allow sodium into the cell.
C) The S4 helices rotate, shifting the position of the S6 helices to open the ion pore.
D) A group of negatively-charged amino acids along the C-terminus rotate to open the ion pore.
E) A short loop between S4 and S5 swings open to allow sodium into the cell.