What Is the Central Mechanism for Establishing Self-Tolerance

Multiple Choice

What is the central mechanism for establishing self-tolerance?

A) Self-reactive T cells and B cells are killed during development.
B) Individuals that have immune systems that respond to self-antigens do not survive to reproduce.
C) Immune cells that react to self-antigens are turned off when they recognize self-tissues.
D) Certain immune suppressive cytokines are maintained in tissues to dampen auto reactive immune responses.
E) Peripheral tissues have mechanisms to kill T or B cells that respond to them.