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How Do Autoimmune Diseases Like Rheumatoid Arthritis, Type I Diabetes

Question 55

Multiple Choice

How do autoimmune diseases like rheumatoid arthritis, Type I diabetes and Multiple Sclerosis develop?


A) During maturation, negative selection fails to eliminate Class II MCH phagocytes with autoreactive receptors at checkpoint 1.
B) During maturation, negative selection fails to eliminate lymphocytes with autoreactive receptors at checkpoint 2.
C) There is an error during clonal expansion that generates an over-abundance of non-specific lymphocytes.
D) During clonal deletion, the TREG cells that suppress the development of autoimmune diseases are accidentally eliminated.

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