Question 1

The DNA polymerase inhibitor aciclovir can suppress the symptoms of several viral infections except:

Accepted Answer

A)   chickenpox.
B)   herpes type I.
C)   measles.
D)   Epstein-Barr infections. C

Question 2

Which of the following is not a likely cause of antimicrobial resistance?

Accepted Answer

A)   Using narrow-spectrum antibiotics instead of broad-spectrum antibiotics.
B)   Excessive use of antibiotics in animals bred for human consumption.
C)   Failure to conform to the dosing regime.
D)   Spraying excess antibiotic in the air after drawing it up for injection. A

Question 3

What medication regime is ineffective in treating microorganisms that are part of the ESCAAPPM group?

Accepted Answer

A)   A carbapenem agent.
B)   A penicillin agent.
C)   An aminoglycoside agent.
D)   A fluoroquinolone agent. B

Question 4

Which one of the following drug groups directly targets the intracellular cascade of reactions leading to proliferation and survival of cancerous cells?

Accepted Answer

A)   S-phase inhibitors.
B)   Monoclonal antibodies.
C)   Radioactive samarium.
D)   Protein kinase inhibitors.

Question 5

The antiviral agents called neuraminidase inhibitors are useful in treating:

Accepted Answer

A)   HIV/AIDS infection.
B)   respiratory syncytial virus infection.
C)   herpes infection.
D)   influenza infection.

Question 6

A drug used to treat amoebiasis is:

Accepted Answer

A)   vancomycin.
B)   tinidazole.
C)   niclosamide.
D)   pyrantel.

Question 7

Which tests should be regularly undertaken during rifampicin therapy?

Accepted Answer

A)   Monitor the full blood count and liver function during the course of therapy.
B)   Monitor electrolyte levels and cardiac function during the course of therapy.
C)   Monitor renal function and exercise tolerance during the course of therapy.
D)   Monitor hearing and eye function during the course of therapy.

Question 8

A typical drug combination in the first-line treatment of leprosy is:

Accepted Answer

A)   thalidomide and ofloxacin.
B)   minocycline and prednisolone.
C)   clofazimine and cycloserine.
D)   dapsone and rifampicin.

Question 9

Ancestim, a colony stimulating factor, should not be given ________ before or after cytotoxic therapy dosing.

Accepted Answer

A)   6 hours
B)   12 hours
C)   24 hours
D)   48 hours

Question 10

An antituberculotic drug with a sterilising action is:

Accepted Answer

A)   isoniazid.
B)   ethambutol.
C)   rifampicin.
D)   gentamicin.

Question 11

In the context of antituberculotic drug action, a bactericidal drug:

Accepted Answer

A)   kills all tuberculosis bacteria.
B)   targets dividing bacteria.
C)   kills persistent dormant bacteria.
D)   targets bacteria in the lungs.

Question 12

Which one of the following is not considered a current problem associated with gene therapy?

Accepted Answer

A)   Viral vectors are the only means of delivering genes to cells.
B)   The treatment may induce cancer in the client receiving gene therapy.
C)   The proportion of target cells in a tissue that receive the inserted gene is low.
D)   Defective genes cannot be replaced or removed.

Question 13

The desired therapeutic effect of colony stimulating factors are to:

Accepted Answer

A)   increase the rate of colonisation of bacteria within a suspension.
B)   increase the numbers of circulating leukocytes.
C)   increase the heart rate.
D)   increase the rate of platelet aggregation.

Question 14

Which of the following antimicrobial agents inhibits DNA replication?

Accepted Answer

A)   Linezolid.
B)   Mupirocin.
C)   Colistin.
D)   Norfloxacin.

Question 15

The most active agent for leprosy is:

Accepted Answer

A)   dapsone.
B)   rifampicin.
C)   thalidomide.
D)   streptomycin.

Question 16

Which one of the following is not a common adverse effect of HIV treatment with the viral protease inhibitor atazanavir?

Accepted Answer

A)   Photosensitivity.
B)   Nausea or vomiting.
C)   Diarrhoea.
D)   Lipodystrophy.

Question 17

Malaria can be caused by at least ________ species of Plasmodium.

Accepted Answer

A)   2
B)   3
C)   4
D)   5

Question 18

Administration of the antibacterial agent ________ may cause prolongation of the QT interval and development of serious ventricular dysrhythmias.

Accepted Answer

A)   erythromycin or clarithromycin
B)   benzylpenicillin or amoxycillin
C)   tetracycline or doxycycline
D)   gentamicin or tobramycin

Question 19

Which drug group is considered a suitable alternative to penicillins when there is a known allergy?

Accepted Answer

A)   The macrolides.
B)   The cephalosporins.
C)   Gycopeptide antibacterials such as vancomycin.
D)   The quinolones.

Question 20

The species of malaria that causes the most infections is.

Accepted Answer

A)   P. ovale
B)   P. malariae
C)   P. vovax
D)   P. falciparum

Exam 14: The Modulation of Celullar Growth and Proliferation